Determining the "best" hotel in Karachi can depend on various factors such as location, amenities, service, and personal preferences. However, here are some of the top hotels in Karachi based on factors like reputation, reviews, and popularity:

1. Pearl Continental Hotel Karachi: One of the most renowned hotels in Karachi, the Pearl Continental Hotel offers luxurious accommodations, excellent dining options, and extensive facilities including swimming pools, fitness center, and spa.

2. Movenpick Hotel Karachi: Known for its elegant design and modern amenities, Movenpick Hotel Karachi provides upscale accommodations, multiple dining options, and top-notch service, catering to both business and leisure travelers.

3. Marriott Karachi: The best hotels in karachi is a favorite among travelers for its convenient location, spacious rooms, and excellent hospitality. With its range of dining options and recreational facilities, it's a popular choice for both business and leisure travelers.

4. Avari Towers Karachi: A landmark in the city, Avari Towers Karachi offers luxurious accommodations, fine dining restaurants, and extensive facilities including a swimming pool, fitness center, and spa, making it a preferred choice for discerning travelers.

5. Ramada Plaza Karachi: Ramada Plaza Karachi boasts modern and comfortable accommodations, along with a range of dining options and facilities including a rooftop swimming pool and fitness center, making it a popular choice for both business and leisure travelers.

6. The Westin Karachi: Situated in the heart of the city, The Westin Karachi offers upscale accommodations with contemporary amenities, multiple dining options, and wellness facilities including a spa and fitness center, catering to both business and leisure travelers.

7. Dreamworld Resort, Hotel & Golf Course: Located cheap hotels in karachi, Dreamworld Resort offers a serene retreat with lush greenery, spacious rooms, recreational facilities, and a golf course, making it a popular choice for a relaxing getaway.

These are just a few of the top hotels in Karachi, each offering its own unique features and amenities. It's recommended to research further based on your specific preferences and requirements to find the best hotel that suits your needs during your stay in Karachi. Additionally, reading recent reviews and checking current availability and rates can also help in making an informed decision.